ABSTRACT:
Excipients perform major role in manufacturing of different tablet formulations. Excipients which mainly effect the disintegration time of any formulation are disintegrants, super disintegrants, polymers, surfactants etc. The technologies like spray drying, molding, cotton candy, lyophilization etc are generally employed for manufacturing of tablets such as dispersible tablet (DTs) and orodispersible tablets (ODTs) or fast dissolving tablets (FDTs) also effect disintegration time of these formulations. Exipients can act by different mechanism such as capillary action, capillary absoption, swelling action. Dispersible tablets cover broad advantages over other dosage forms, in respect to onset of action, bioavailability and patient compliance. These formulations provide better efficacy to treat the patient. Formulation of tablets along with disintegrantes/superdisintegrants or with other excipients which can enhance the solubility of dosage forms, so selection of better compatible excipients is necessary. Commonly used disintegrating agents are Isapghula hask, Cassia tora, Cassia nodosa, Crosslinked tragacanth which have been employed in much drug formulation. The study of different disintegrating substances in formulations gives important information for optimizing the dosage forms for better efficacy.