ABSTRACT:
Ibuprofen is non-steroidal anti inflammatory drug (NSAID) drug which used for relief of symptoms of arthritis, primary dysmenorrheal, and fever and as an analgesic. The aim of this study was to develop high sensitive, selective and rapid quantitative analytical method for estimation of ibuprofen as well as evaluation of marketed tablet of ibuprofen (Brufen400). The drug shows absorption maxima at 221nm. The liner dynamic response was found to be in the concentration of 2-20µg/ml. The slop, intercept and correlation coefficient were found to be 0.1256, 0.0581 and 1 respectively. The estimated amount of ibuprofen in marketed tablets was found to be 99.80±0.12%. The marketed tablets evaluated for weight variation, hardness, friability, and disintegration time and dissolution study. The tablets show acceptable weight variation as per pharmacopoeial specification. Friability shows below 1% indicating good mechanical resistance of tablets. The marketed tablet shows average 5.4 kg/cm2 hardness which indicate good strength of tablets. The disintegration time varies from 5.53 min. to 7.34 min. and 97.16% drug release in 50 minutes. The newly developed method and the evaluation of marketed tablets can be used for analysis of ibuprofen of equal significant drug as well as evaluation parameters can be help for quality control and quality assurance of the drug.