ABSTRACT:
Peptic ulcer is the disorder of the upper gastro intestinal tract; hyperacidity is one of the main causes of peptic ulcer. Worldwide accepted clinical therapy of acid disease is based on H2 receptor antagonists. The four H2 receptor antagonists currently available on market are cimetidine, ranitidine, famotidine, and nizatidine. Of the various technologies for gastro retentive dosage forms, the floating drug delivery system (FDDS). It’s widely investigated since they are most promising dosage form to achieve reproducibility in a wide spectrum of biological conditions. This article presents, Factors affecting the gastric emptying and, hence, the gastric retention time of oral dosage forms , advantages and disadvantages of floating drug delivery system, potential drug candidates for gastroretentive drug delivery systems, drugs those are unsuitable for gastroretentive drug delivery systems, mechanism of floating systems, classification of anti ulcer drugs, H2 receptor antagonists pharmacology, approaches of floating drug delivery system based on the mechanism of buoyancy, gastroretentive products available in the market, evaluation parameters.