ABSTRACT:
The objective of the present study is to develop colon targeted drug delivery system (CDDS) by using different polysaccharides as a carrier for aceclofenac. Matrix tablets containing various excipients and polysaccharide were prepared by wet granulation technique using different binder systems. The tablets were evaluated by different IPQC tests, content uniformity and in-vitro drug release study. Drug release profile was evaluated in simulated gastric, intestinal fluid and simulated colonic fluid. The matrix tablet containing dextrin as a carrier and ethyl cellulose as binder was found to be suitable for targeting aceclofenac for local action in the colon as compare to other matrix tablets containing different binders. Tablets containing dextrin released 83-84 % of aceclofenac in simulated colonic fluid. Tablets containing dextrin showed no change in dissolution profile upon storage at 40 C / 75 % relative humidity for three months. In-vitro study indicate that matrix tablets containing dextrin as carrier and ethyl cellulose as binder are most suitable to deliver the drug specifically in colonic region as compare to matrix tablets of dextrin with other binder systems.