ABSTRACT:
Norfloxacin is a common fluoroquinolones antibacterial drug having the bitter taste which hindered its oral administration. Drug resin complex mask the bitter taste of the drug and hence an attempt has been made in the present study to prepare bitterless Norfloxacin suspension using Ion exchange resins. Norfloxacin was treated with the weak cation exchange resins which form the drug resin complex called resinate. The loading process was optimized for the pH of loading solution and the drug resin ratio. The resinates were evaluated for bulk density, angle of repose, taste masking, and in vitro drug release. Taste evaluation of the drug resinates showed complete masking of the bitterness of the drug. In vitro drug release studies revealed that more than 90% of the drug was released within 20 min from the drug resinates. Sweet palatable aqueous suspension of norfloxacin was formulated successfully with drug-resin complex and it was found to be stable.