ABSTRACT:
Two simple new visible spectrophotometric methods have been developed for determination of Ramipril, in single component pharmaceutical dosage forms. The methods were based on the formation of ion-pair complexes of the drug with dye Bromocresol Green (BCG) and Bromo Cresol purple (BCP), in acidic buffer solutions followed by their extraction in chloroform. Experiments were carried out to optimize the reaction conditions for complete colour formation. It was found that 5 ml BCG and BCP reagents and 5 ml of buffer solutions were optimum for the achievement of maximum colour intensity. BCG with Acid phthalate buffer of pH3 gave more absorbance at 415 nm this process was optimized (with BCP 405nm)The optical charactersic such as beer’s law, correlation coefficient, slope, Y intercept, and Molar absorptivity were calculated for all the methods and the analysis results of marketed formulations were in good agreement with their labeled claim. The recovery ranged from between 98 to 100 % for BCG and BCP which comply with official limits. The proposed methods were simple, sensitive, accurate and precise and can be successfully applied for the estimation of Ramipril. Results of the method were validated statistically and by recovery studies, this method was demonstrated to be adequate for routine analysis.