ABSTRACT:
In the present study evaluation of the effect of Quercus infectoria olivier (fagaceae) in experimentally induced inflammatory bowel disease in rats was carried out for that Sprague Dawley rats (200-300 gm) of either sex were randomly allocated to 6 groups (n=6). Except Group I (normal) and II (vehicle control) colitis was induced on 11th day by N-ethylmaleimide (NEM, 3%, 0.1 ml, intrarectally) in animals of groups III (model control), IV (std), V (test-300 mg/kg p.o) and VI (test-450 mg/kg p.o). 5-Amino salicylic acid (100 mg/kg p.o), Quercus infectoria 300 mg/kg and 450 mg/kg was administered to groups IV, V and IV respectively for 18 days orally. During the study, animals were observed for various physical parameters .On 18th day of study rats were sacrificed, colon was scored histologically and various antioxidant parameters were measured in isolated colon tissue. Treatment with 5-Amino salicylic acid, Quercus infectoria significantly prevented the changes induced by NEM in physical and oxidative stress parameters. There was also significant improvement in histological scoring like colon mucosal damage index (CMDI), disease activity index (DAI), microscopic scoring, macroscopic scoring and histopathology of treatment groups as observed in group III. So, the results of our study suggest that Quercus infectoria therapy has beneficial effects on the course of experimental colitis.