Validated Spectrophotometric Method for Estimation of Domperidone in Bulk and Pharmaceutical Formulation

Indrayani D. Raut; Rahul S. Adnaik; Akshada N. Kakade; Sandip A. Bandgar; Dhanyakumar D. Chougule; Rohit. R. Shah

Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)

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Validated Spectrophotometric Method for Estimation of Domperidone in Bulk and Pharmaceutical Formulation

Author(s): Indrayani D. Raut, Rahul S. Adnaik, Akshada N. Kakade, Sandip A. Bandgar, Dhanyakumar D. Chougule, Rohit. R. Shah

Email(s): indrayaniraut7363@rediffmail.com

DOI: Not Available

Address: Indrayani D. Raut1*, Rahul S. Adnaik1, Akshada N. Kakade1, Sandip A. Bandgar2, Dhanyakumar D. Chougule3 and Rohit. R. Shah3
1 Rajarambapu College of Pharmacy, Kasegaon.
2Ashokrao Mane College of Pharmacy, Peth-vadgaon.
3Appasaheb Birnale College of Pharmacy, Sangli.
*Corresponding Author

Published In: Volume - 4, Issue - 5, Year - 2011

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ABSTRACT:
Domperidone is a synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist with antiemetic properties. Various methods for analysis of same are available but are time consuming and expensive. Various simultaneous method of Domperidone with another drug is available. Here we have developed new, precise, simple spectrophotometric method for estimation of Domperidone from bulk. Medium prepared were selected 0.1 N HCl having pH 1.2. It showed absorption maxima at 284nm.This method were validated according to ICH guidelines. The drug obeyed Beers law and showed good correlation. The linearity was observed between 0–20 mcg/mL. There was no significant difference in the intraday and interday analysis of Domperidone determined. The results of analysis were validated with respect to recovery, linearity; Limit of detection and limit of quantitation were found to be satisfactory.

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Cite this article:
Indrayani D. Raut, Rahul S. Adnaik, Akshada N. Kakade, Sandip A. Bandgar, Dhanyakumar D. Chougule, Rohit. R. Shah. Validated Spectrophotometric Method for Estimation of Domperidone in Bulk and Pharmaceutical Formulation. Research J. Pharm. and Tech. 4(5): May 2011; Page 790-792.

Cite(Electronic):
Indrayani D. Raut, Rahul S. Adnaik, Akshada N. Kakade, Sandip A. Bandgar, Dhanyakumar D. Chougule, Rohit. R. Shah. Validated Spectrophotometric Method for Estimation of Domperidone in Bulk and Pharmaceutical Formulation. Research J. Pharm. and Tech. 4(5): May 2011; Page 790-792. Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2011-4-5-37

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