ABSTRACT:
The aim of this study was to investigate the physicochemical properties of Nateglinide in inclusion complex. The phase solubility behavior of Nateglinide in presence of various concentrations of ß-CD in pH 7.4 buffers was obtained at 370C. The solubility of Nateglinide increased with increasing the concentration of ß-CD. The inclusion complex of Nateglinide with ß-CD were prepared at in various ratios (C1-1:1 Nateglinide: ß-CD, C2-1:2 Nateglinide: ß-CD, C3-1:3 Nateglinide: ß-CD) using Kneading method. Prepared inclusion complexes were evaluated by FT-IR, LC-MS, DSC, NMR and SEM. The FT-IR spectroscopic studies showed the stability of Nateglinide and absence of well-defined Nateglinide- ß-CD interaction. Among all prepared inclusion complexes, C3 showed the best release pattern.
Cite this article:
Anusuya Patil, B.G. Desai, H. N. Shivakumar, Purvang. Enhancement of Nateglinide Solubility and Dissolution Rate. Research J. Pharm. and Tech. 4(7): July 2011; Page 1159-1164.
Cite(Electronic):
Anusuya Patil, B.G. Desai, H. N. Shivakumar, Purvang. Enhancement of Nateglinide Solubility and Dissolution Rate. Research J. Pharm. and Tech. 4(7): July 2011; Page 1159-1164. Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2011-4-7-27