ABSTRACT:
The Present work deals with the investigation of CNS depressant and analgesic activities of the ethanol, ethyl acetate, chloroform and petroleum ether extracts of Tephrosia purpurea root using actophotometer for CNS depressant activity and analgesic activity using Tail immersion method in albino rats of both sexes. Animals were divided in to ten groups each consisting of six animals. Group 1 served as control and Group 2 received standard drug. Group 3 to Group 10 were assigned for our investigation. Group 3 received ethanol extract of 250 mg/kg and Group 4 received 500 mg/kg ethanol extract of Tephrosia purpurea root. Group 5 treated with ethyl acetate extract 250 mg/kg and Group 6 treated with 500 mg/kg ethyl acetate extract of Tephrosia purpurea root. Group 7 received chloroform extract 250 mg/kg and Group 8 received 500 mg/kg chloroform extract of Tephrosia purpurea root. Group 9 injected with petroleum ether extract 250 mg/kg and Group 10 received 500 mg/kg petroleum ether extract of Tephrosia purpurea root. The result of the study reflected that all the extracts of Tephrosia purpurea root were found to possess CNS depressant and analgesic activities. Among the above four extracts ethanol extract of Tephrosia purpurea root of 500 mg/kg possessed higher CNS depressant activity (89.04%) with a probability <0.001 and it also possessed approximately similar analgesic activity as that of standard analgesic drug diclofenac sodium after 120 minutes .