ABSTRACT:
The objective of this study was to design wax matrix tablets for oral sustained release of Metoprolol succinate and to investigate the sustained release behavior of the fabricated tablets. Matrices were prepared by melt granulation technique using Hydrogenated vegetable oil, Compritol and Precirol as a release retardant material. The FT-IR study indicated the compatibility of drug with excipients. The effect of different wax materials, different ratio of wax materials and excipients on release profile of metoprolol succinate was also studied. Tablet matrices containing dicalcium phosphate has given more retardant effect on release of drug than other excipients. One of the best formulations further studied for sintering time and temperature effect using direct compression method. Matrix tablet showed no change in physical appearance, drug content after storage 400C/ 75% RH for 3 months.
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