ABSTRACT:
Difficulty in swallowing leads to non-compliance and subsequently leading to ineffective therapy. New era is an era of novel drug delivery system. Formulation research is oriented towards increasing safety and efficacy of existing drug molecule through novel concept of drug delivery and these target can be achieved by formulating drug with suitable polymer or polymers combination. Terbutaline Sulphate is a beta-2 agonist and has action similar to that of Isoproterenol. The basic aim of this formulation was to decrease the onset time of the drug by decreasing the disintegration time of the tablet by formulating fast dissolving tablet. In the present study fast dissolving tablets of Terbutaline Sulphate was prepared by using of various polymers. The tablets were prepared by direct compression technique. The prepared tablets were evaluated for general appearance, hardness, weight variation, friability, in-vitro disintegration time. In vitro disintegration time studies showed a drug release up to 91 to 98% in 3 min. that was found to be better than a commercial product (86%) in 1 hrs. The formulation were subjected to stability testing for two months at accelerated condition result revealed that no significance change in formulation of final batch.