Author(s):
Anuruddha R. Chabukswar1*, Bhanudas S. Kuchekar1, Pradeep D. Lokhande2, Archana S. More3, Neha S. Ojha1, Ashwini M. Londhe1
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1Maharashtra Academy of Engineering And Educational Research’s , Maharashtra Institute of Pharmacy S.No.124, MIT Campus, Paud Road, Pune- 411038,M.S.,India.
2Department of Chemistry, University of Pune, Pune- 411007, M.S., India.
3J.S.P.M.’s Jayawan
Published In:
Volume - 5,
Issue - 10,
Year - 2012
ABSTRACT:
Present work describes the synthesis of (2E)-1-(8-hydroxyquinolin-7-yl)-3-(Aryl) prop-2-en-1-one, derivatives of Chalcones. Starting material 8- hydroxy quinoline was acetylated and subjected to fries rearrangement reaction to yield 7-acetaldehyde-8-hydroxy quinoline which on aldol condensation with various derivatives of benzaldehyde yields 13 compounds. The compounds have been characterized and evaluated for anti-bacterial activity. MIC values of the compounds showing higher zone of inhibition was found to be 100 µg/ml. The activity of the compounds can be attributed to the substitution of electronegative groups in the synthesized compounds.
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