Author(s):
D. V. Madat, M. C. Gohel, A.Ramkishan
Email(s):
dhavalmadat@gmail.com
DOI:
Not Available
Address:
D. V. Madat1, M. C. Gohel2 and A.Ramkishan3
1 D. D. University, Nadiad, Gujarat.
2Ahmadabad University, Ahmadabad, Gujarat.
3 Deputy Drugs Controller (II), I/C, CDSCO Zonal Office, Ahmadabad, Gujarat.
*Corresponding Author
Published In:
Volume - 5,
Issue - 10,
Year - 2012
ABSTRACT:
The objective of the present investigation was to develop controlled release matrix pellets of venlafaxine HCl using the concept of design of experiments. Extrusion-spheronization technique was adopted for the preparation of the matrix pellets of venlafaxine HCl employing ethyl cellulose (EC) and polyethylene oxide (PEO) as insoluble and soluble matrixing agents respectively. Hydroalcoholic fluid was used as a binder to facilitate pellet formation. The pellets were assessed for flow property and friability. Media change method was used to study the in vitro dissolution pattern of venlafaxine HCl. Model fitting was carried out to identify the most valid kinetics of drug release. The use of hydroalcoholic medium, in place of water, facilitated processing without sticking. The pellets exhibited good flow and low friability. The drug was released at a controlled rate from the formulated product. Multiple regression analysis was used to evolve mathematical models for drug release at 2, 6 and 12 hr. Response surface plots were drawn to visualize the impact of independent variables on drug release. The drug release at 2, 6 and 12 hr was influenced by the amount of EC and PEO. The kinetics of drug release was best explained by Weibull model. The drug was released by non-fickian diffusion. The use of systematic formulation study is advantageous for the development of CR pellets of venlafaxine HCl. The optimum batch consisted of 37.5 mg venlafaxine HCl, 30% EC and 20% PEO.
Cite this article:
D. V. Madat, M. C. Gohel, A.Ramkishan. Development of Venlafaxine Hydrochloride Controlled Release Pellets Prepared Employing the Blend of Ethyl Cellulose and Polyethylene Oxide. Research J. Pharm. and Tech. 5(10): October 2012; Page 1289-1292.
Cite(Electronic):
D. V. Madat, M. C. Gohel, A.Ramkishan. Development of Venlafaxine Hydrochloride Controlled Release Pellets Prepared Employing the Blend of Ethyl Cellulose and Polyethylene Oxide. Research J. Pharm. and Tech. 5(10): October 2012; Page 1289-1292. Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2012-5-10-40
REFERENCES:
1. Weiss NT, Jones L, Chamberlain JC. A possible case of venlafaxine-induced Stevens-Johnson syndrome. J Clin Psychiatry. 2004, 65(10), 1431-1433.
2. Olver JS, Burrows GD, Norman TR. The treatment of depression with different formulations ofvenlafaxine: a comparative analysis. Hum Psychopharmacol., 2004, 19(1), 9-16.
3. Alderman DA. A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage forms. Int J Pharm Tech Prod Mfr. 1984, 5, 1-9.
4. Anurag S, Ramesh P. Design of controlled release delivery systems using a modified pharmacokinetic approach: a case study for drugs having a short elimination half-life and a narrow therapeutic index. Int J Pharm. 2003, 261(1-2), 27-41.
5. Najib N, Suleiman MS. The kinetics of drug release from ethylcellulose solid dispersions. Drug Dev Ind Pharm. 1985, 11(12), 2169-2181
6. Li CL, Martini LG, Ford JL, Roberts M. The use of hypromellose in oral drug delivery. J Pharm Pharmacol. 2005, 57(5), 533-546.
7. Chattaraj SC, Das SK. Effect of formulation variables on dissolution profile of dictlofenac sodium from ethyl- and hydroxylpropylmethyl cellulose tablets. Drug Dev Ind Pharm. 1996, 22(7), 555-.559.
8. Latfi G, Esmaeil J. Preparation and in vitro evaluation of controlled release hydrophilic matrix tablets of ketorolac tromethamine using factorial design. Drug Dev Ind Pharm. 2008, 34(8), 903-910.
9. Lee BJ, Ryu SG, Cui JH. Formulation and Release Characteristics of Hydroxypropyl Methylcellulose Matrix Tablet Containing Melatonin. Drug Dev Ind Pharm. 1999, 25(4), 493-501.
10. Tiwari SB, Murthy TK, Pai MR, Mehta PR, Chowdary PB. Controlled release formulation of tramadol hydrochloride using hydrophilic and hydrophobic matrix system, AAPS PharmSciTech. 2003, 4(3), article 31.
11. Samani SM, Montaseri H, Kazemi A. The effect of polymer blends on release profiles of diclofenac sodium from matrices. Eur J Pharm Biopharm. 2003, 55(3), 351-355.
12. Colombo, P., Sweling-controlled release in hydrogel matrices for oral route, Advanced Drug Delivery Reviews, 1993, 11, 37
13. Mandal S., Basu S., Biswanath S., Sustained Release of a Water-Soluble Drug from Alginate Matrix Tablets Prepared by Wet Granulation Method, AAPS PharmSciTech, 2009, 10, 1348
14. Chopra S., Patil G., Motwani S., Release modulating hydrophilic matrix systems of losartan potassium: Optimization of formulation using statistical experimental design, European Journal of Pharmaceutics and Biopharmaceutics, 2007, 66, 73
15. Petrovic A, Cvetkovic N, Ibric S., Trajkovic S., Djuric Z., Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose, Archives of Pharmacal Research, 2009, 32, 1767