ABSTRACT:
The present study was designed to investigate the cardioprotective effect of ethanolic extract of Buchanania lanzan Spreng. (EEBL) against isoproterenol induced myocardial infarction in rats by studying myocyte injury markers, antioxidant defense system, serum and electrocardiographic changes. Wistar rats were randomly divided into five groups, namely control, EEBL control, isoproterenol control, 250 mg/kg EEBL+ isoproterenol and 500 mg/kg EEBL + isoproterenol treated group. EEBL treatment group received EEBL (250 and 500 mg/kg/day, p.o) for 30 days. Myocardial infarction in rats was induced by isoproterenol administration (200 mg/kg, s.c.) at an interval of 24 h on 29th and 30th day. On 30th day ECG, biochemical parameters were assessed. Isoproterenol administration showed changes in ECG pattern, including ST-segment elevation (diagnostic of myocardial infarction) increase in the serum levels of cardiac injury markers (Creatine kinase-MB, lactate dehydrogenase, aspartate transaminase and alanine transaminase), decreased antioxidant defense system in the heart. EEBL pre-co-treatment prevented almost all the parameters of isoproterenol induced myocardial infarction in rats. Results of the present study suggest that EEBL has a significant effect on the protection of the heart against isoproterenol induced myocardial infarction through maintaining endogenous antioxidant enzyme activities.