ABSTRACT:
Hepato protective activity of Tinospora cordifolia was evaluated against paracetamol (acetaminophen) and alcohol induced hepatic damage in male albino rats. Hepatic damage was well manifested by significant increase in the activities of Alanine amino transferase, Aspartate amino transferase. Alkaline phosphatase, Lactate dehydrogenase in serum and enhanced lipid peroxidation. On the other hand, the activities of Superoxide dismutase, Catalase in Liver tissue were lowered. Consequent to paracetamol induced hepatic injury, the serum Bilirubin level was increased. Paracetamol toxicity, also resulted in significant reduction in total serum protein, Vitamin-E and Vitamin-C. The oral administration of varying doses of ethanolic extract of Tinospora cordifolia (10, 20, 30 mg/kg body weight ) for the period of 7 days reversed these altered parameters to normal levels indicating the hepato protective efficacy of Tinospora cordifolia against paracetamol induced liver injury.