ABSTRACT:
Two simple, sensitive, accurate and precise spectrophotometric methods were developed and validated for quantitative determination of Paracetamol (PCT) and Cinnarizine(CINN) in tablet dosage form. Method I is based on the simultaneous equation, and Method II is based on the absorbance ratio method. The absorption maxima were found to be at 244 nm and 254 nm in 0.1 N Hydrochloric acid for the two drugs. Beer's law is obeyed in the concentration range of 5-25 µg/ml for paracetamol and cinnarizine with correlation coefficient within range of 0.998 - 0.996 for the two drugs. The simultaneous equation method is based on the additivity of absorbances and the absorbance ratio method involves determination of the ratio of absorbance at 254 nm, the absorption maxima of cinnarizine and isoabsorptive wavelength 248 nm. The accuracy of the methods was assessed by recovery studies and was found to be 99.58 ± 0.34 and 100.25 ± 0.17 by the simultaneous equation method, 100.16± 0.49 and 100.05 ± 0.39 by the absorbance ratio method for Paracetamol and Cinnarizine respectively.