ABSTRACT:
The liver plays a central role in transforming and clearing chemicals. Liver has one of the highest value of importance for the systemic detoxification and deposition of endogenous and exogenous substances. Liver diseases are considered to be serious health disorders. Liver dysfunction that challenges not only health care professionals but also the pharmaceutical industry and drug regulatory agencies. Drug-induced liver injury (DILI) possesses a major clinical problem. DILI has become the leading cause of acute liver failure and transplantation in Western countries. Certain medicinal agents, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the organ. Other chemical agents, such as those used in laboratories (Thioacetamide, alcohol etc) and industries, natural chemicals (eg. microcystins) are induce hepatotoxicity. Modern medicines have little to offer for alleviation of hepatic diseases also they lead further damage to the liver. Hence plant based preparations which are employed for their treatment of liver disorders. Therefore, many folk remedies from plant origin are tested for its potential antioxidant and hepatoprotective liver damage in experimental animal model. Therefore the present review is aimed at compiling data based on pharmacologically active phytochemicals from medicinal plants that have been investigated in various hepatotoxicity animals models.