Author(s):
Nowshin Nowaz Rumzhum, Mostafizur Rahman, AFM Rafiu-Ul Islam
Email(s):
hasanmostafiz@yahoo.com
DOI:
Not Available
Address:
Nowshin Nowaz Rumzhum, Md. Mostafizur Rahman*, AFM Rafiu-Ul Islam
Laboratory of Pharmacognosy and Pharmacology, Department of Pharmacy, Stamford University Bangladesh, Dhaka-1217, Bangladesh
*Corresponding Author
Published In:
Volume - 5,
Issue - 5,
Year - 2012
ABSTRACT:
Crude ethanolic extract of flowers of Couroupita guianensis Aubl. (Family: Lecythidaceae) was evaluated for central nervous system (CNS) depressant effects using a number of neuropharmacological experimental models in Swiss-albino mice. The extract produced a dose-dependent reduction of the onset and duration of pentobarbitone-induced hypnosis, reduction of locomotor and exploratory activities in the open field and hole cross studies. Further, at the same dose level the extract inhibited acetic acid-induced writhing in mice in dose-dependent manner. These results suggest that the extract possess CNS depressant activity, which support the traditional uses of Couroupita guianensis
Cite this article:
Nowshin Nowaz Rumzhum, Mostafizur Rahman, AFM Rafiu-Ul Islam. CNS Depressant Effect of Crude Ethanolic Extract of Flowers of Couroupita guianensis Aubl. in Swiss-albino Mice. Research J. Pharm. and Tech. 5(5): May2012; Page 615-618.
Cite(Electronic):
Nowshin Nowaz Rumzhum, Mostafizur Rahman, AFM Rafiu-Ul Islam. CNS Depressant Effect of Crude Ethanolic Extract of Flowers of Couroupita guianensis Aubl. in Swiss-albino Mice. Research J. Pharm. and Tech. 5(5): May2012; Page 615-618. Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2012-5-5-18