ABSTRACT:
The aim of the current study was the development of Esomeprazole buccal adhesive tablets using direct compression. Buccoadhesive tablets of Esomeprazole which were designed to prolong the buccal residence time after oral administration. Buccal adhesive formulations were developed using with various combinations of mucoadhesive polymers namely, Carbopol 934 P, HPMC K4M, sodium alginate. The prepared Esomeprazole tablets were evaluated for weight variation, thickness, hardness, surface PH, content uniformity and swelling index. In-vitro drug Permeation Studies by egg membrane, ex-vivo drug Permeation Studies by goat membrane. The effect of formulation composition on the release pattern was also investigated. Most formulations showed Esomeprazole controlled release profiles depended on the grade and polymer ratio. Tablets containing Carbopol 934 P and sodium alginate in the ratio of 1:1(B3) showed the maximum drug release of 94.16% in 8 hours. The swelling index was proportional to sodium alginate content and inversely proportional to Carbopol 934 P content. Formulation B3 showed maximum swelling index after 6 hours. The surface pH of all tablets was found close to neutral PH. The release mechanisms were found to fit Peppas’ kinetic model.
Cite this article:
A. Bari, Shialesh N. Sharma, Yashwant T. Dangat, Swati C. Jagdale, Aniruddha R. Chabukswar, Bhanudas S. Kuchekar. Controlled Release from Directly Compressible Esomeprazole Buccal Tablet. Research J. Pharm. and Tech. 5(5): May2012; Page 652-657.
Cite(Electronic):
A. Bari, Shialesh N. Sharma, Yashwant T. Dangat, Swati C. Jagdale, Aniruddha R. Chabukswar, Bhanudas S. Kuchekar. Controlled Release from Directly Compressible Esomeprazole Buccal Tablet. Research J. Pharm. and Tech. 5(5): May2012; Page 652-657. Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2012-5-5-23
REFERENCES:
1. Bhanja1S, Ellaiah P, Martha SK,
Sahu PK, Tiwari SP, Formulation and in vitro evaluation of mucoadhesive buccal
tablets of Timolol maleate, Int J Pharm Biomed Res, 1(4); (2010):129-134.
2. Boyapally H, Nukala RK, Bhujbal
P, Douroumi D, Controlled release from directly compressible theophylline
buccal tablets, Colloids and Surfaces B: Biointerfaces, 77;(2010):227-233.
3. Chandira M, Mehul, Debjit,
Chiranjib, Kumudhavalli, Formulation, Design and Development of Buccoadheshive
Tablets of Verapamil Hydrochloride, International Journal of PharmTech
Research, 1(4);2009:1663-1677.
4. Alagusundaram M, Chengaiah B,
Ramkanth S, Angala Parameswari S,
Formulation and Evaluation of Mucoadhesive Buccal Films of Ranitidine,
International Journal of PharmTech Research, 1(3); 2009: 557-563.
5. Jafar A, Ali Nokhodchi, Djavad
F, Massoud A, Development and evaluation of buccoadhesive propranolol
hydrochloride tablet formulations: effect of fillers, IL Farmaco, 59;
(2004):155-161.
6. Emami J, Varshosaz J,
Saljoughian N, Development and evaluation of controlled-release Buccoadhesive
verapamil hydrochloride tablets, DARU, 16(2); 2008:60-69.
7. Sudhakar Y, Kuotsu K,
Bandyopadhyay AK, Buccal bioadhesive drug delivery-A promising option for
orally less efficient drugs, Journal of Controlled Release 114; (2006): 15-40.
8. Nair AB, Gupta R, Kumria R,
Jacob S; Formulation and Evaluation of Enteric Coated Tablets of Proton Pump
Inhibitor, Jour of Basic and Clinical Pharmacy, 1(4); (2010):215-221.
9. Basawaraj SP, Sandeep ST,
Hariprasanna RC, Gururaj VW; Development and In-Vitro Evaluation of
Mucoadhesive Buccal Tablets of Tizanidine Hydrochloride using Natural Polymer
Xanthan Gum, International Journal of Pharmaceutical Science Review and
Research, 8(2);(2011): 140-146.
10. Rajesh Khanna, SP Agarwal, Alka
Ahuja; preparation and evaluations of bioerodiable buccal tablet containing
clotriamazole, Inter Jour of Pharmaceutics, 138; (1996): 67-73.
11. Manivannan R, Balasubramaniam A,
Prem Anand DC, Sandeep G; Formulation and In -vitro evaluation of
mucoadhesive buccal tablets of Diltiazem Hydrochloride, Research Journal
of Pharm. and Tech.,
1(4);(2008):478-480.
12. Spiegeleer BD, Vooren LV,
Voorspoels J, Thoné D, Dissolution stability and IVIVC investigation of a buccal
tablet; Analytica Chimica Acta, 446; (2001): 345-351.
13. Ankarao A, Babu rao CH ,Devanna
N, Formulation and Evaluation of Buccoadhesive Bilayered Tablets of Metoprolol
tartrate, International Journal of Research in Pharmaceutical and Biomedical
Sciences, 1(2); (2010):67-71.
14. Luana Perioli, Valeria Ambrogi,
Daniela Rubini, Stefano Giovagnoli, Novel mucoadhesive buccal formulation
containing metronidazole for the treatment of periodontal disease, Journal of
Controlled Release, 95; (2004):521-533.
15. Park CR, Munday DL, Development
and evaluation of a biphasic buccal adhesive tablet for nicotine replacement
therapy, International Journal of Pharmaceutics, 237; (2002):215-226.
16. Ikinci G, Senel S, Wilson CG,
Sumnua M, Development of a buccal bioadhesive nicotine tablet formulation for
smoking cessation, International Journal of Pharmaceutics, 277; (2004):173-178.
17. Choi HG , Jung JH , Yong CS ,
Rhee CD, Formulation and in vivo evaluation of omeprazole buccal adhesive
tablet, Journal of Controlled Release 68;(2000) :405-412.
18. Choi HG, Kima CK, Development of
omeprazole buccal adhesive tablets with stability enhancement in human saliva,
Journal of Controlled Release 68; (2000): 397-404.
19. Nazila SM, Montakarn C, Johnston
TP, The use of mucoadhesive polymers in buccal drug delivery, Advanced Drug
Delivery Reviews, 57; (2005): 1666-1691.
20.
Buket T, Yilmaz, Olgun G, Sirri K, Design and evaluation of
sustained-release and buccal adhesive propranolol hydrochloride tablets,
Journal of Controlled Release, 38; (1996): 11-20.