ABSTRACT:
Ophthalmic drug delivery system is one of the most interesting and challenging approach facing the Pharmaceutical Scientist. The conventional ophthalmic drug delivery system like solution, suspension. Which shows poor bioavailability and therapeutic response because of rapid precorneal drug loss? Utilization of novel ophthalmic drug delivery system an ophthalmic inserts offers an advantage to prolonged drug residence time and a higher bioavailability with respect to conventional ophthalmic drug delivery system. Ocular inserts are sterile preparations, with a thin, multilayered, drug-impregnated, solid or semisolid consistency devices placed into cul-de-sac or conjunctiva sac. They are usually made up of polymeric vehicle containing drug. The therapeutic efficacy of an ocular drug can be greatly improved by prolonging its contact with the corneal surface. Newer ocular drug delivery systems are being explored to develop extended duration and controlled release strategy.