ABSTRACT:
In present world of discovery approximately, near about 40% of new chemical entities exhibit poor aqueous solubility and which is a major challenge to a modern drug delivery system, because of their low bioavailability. The phenomenon of Self-emulsifying drug delivery systems (SEDDS) is widely used to improve the bioavailability of hydrophobic drugs. Self emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. SEDDS can be orally administered in soft or hard gelatin capsules and form ?ne relatively stable oil-in-water (o/w) emulsions upon aqueous dilution due to the gentle agitation of the gastrointestinal ?uids. Conventional SEDDS, however, are mostly prepared in a liquid form, which can produce some disadvantages. Accordingly, Solid SEDDS (S-SEDDS), prepared by solidi?cation of liquid/semisolid self emulsifying ingredients into powders in order to create solid dosage forms, they also gained popularity. This review gives an overview of self emulsifying drug delivery system and the recent advances in the study of SEDDS, especially the related solidification techniques.