ABSTRACT:
Bioenhancers are substances which promote or augment the bioactivity or bioavailability or the uptake of drugs in combination therapy. The present study was undertaken to determine antibacterial potential of a combination that contained pericarp extract of Polyalthia longifolia Thw. (Annonaceae), Cow urine distillate (CUD) and Streptomycin. The antibacterial activity of pericarp extract, CUD, Streptomycin and the combination was determined against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa by Agar well diffusion method. Extract, CUD and antibiotic have shown higher inhibition of Gram positive bacteria. Combination resulted in higher inhibition of test bacteria when compared to antibiotic. Among bacteria, S. aureus was inhibited to more extent followed by P. aeruginosa and others. The combination could be useful in the inhibition of the pathogens as the dosage of antibiotics in the combination is much lesser than the dosage when used alone. The reduction in the antibiotic dosage could result in lesser side effects and also the cost of antibiotic could be reduced. The combination tested in this study could be effective against antibiotic resistant bacteria.