ABSTRACT:
Cefixime is an oral third generation cephalosporin antibiotic. It is very bitter in taste. In the present work an attempt has been made to develop taste masked rapid disintegrating tablet of Cefixime by using ion exchange resins (Tulsion-335, Indion 204 and Indion 214). Different drug: resin ratios were tried to prepare taste masked complex. Depending upon the taste and drug loading efficiency the complex with Tulsion 335 in the 1:1.5 (drug: resin) ratio was selected for the formulation of tablet. Formulated DRC (Drug Resin Complex) was characterized by infrared spectroscopy. Tablets were prepared by direct compression technique using three super disintegrants e.g. croscarmellose sodium, cross povidone and sodium starch glycolate. Tablets formulated with 8% (F2) croscarmellose sodium showed low disintegration time (45 sec), wetting time (50 sec) and friability (0.28%) than the other batches. Formulated tablets of optimized batch (F2) were also compared with the marketed tablet (ZIFI 50). It was concluded from the study that Cefixime shows optimum drug loading with Tulsion-335. Among different superdisintegrants croscarmellose sodium was found suitable.