Author(s): Yogendra Nayak, Jayashree B.S., Unnikrishnan M.K.

Email(s): yogendranayak@gmail.com , yogendra.nayak@manipal.edu

DOI: Not Available

Address: Yogendra Nayak1*, Jayashree B.S.2, Unnikrishnan M.K.3
1Dept of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka – 576104, India
2Dept of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka – 576104, India
3Dept of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka – 576104, India
*Corresponding Author

Published In:   Volume - 5,      Issue - 8,     Year - 2012


ABSTRACT:
Diabetes mellitus (DM) is a metabolic disorder associated with retinopathy, nephropathy, cardiomyopathy, peripheral neuropathy and autonomic neuropathies leading to gastrointestinal, genitourinary, cardiovascular complications and sexual dysfunction. The present available antidiabetic agents are not interferingin the modulation of these complications. Benzopyran-4-one is the basic moiety present in naturally occurring flavonoids. Number of flavonoids hasbeen found to be antidiabetic and many of themmodulate diabetes related complications by acting on newer targets. Hence, an attempt was made to review the possibilities of modulating benzopyran-4-one scaffold for lead optimization in antidiabetic drug discovery.


Cite this article:
Yogendra Nayak, Jayashree B.S., Unnikrishnan M.K. Benzopyran-4-one is an Ideal Pharmacophore for Lead Optimization in Antidiabetic Drug Discovery. Research J. Pharm. and Tech. 5(8): August 2012; Page 1025-1033.

Cite(Electronic):
Yogendra Nayak, Jayashree B.S., Unnikrishnan M.K. Benzopyran-4-one is an Ideal Pharmacophore for Lead Optimization in Antidiabetic Drug Discovery. Research J. Pharm. and Tech. 5(8): August 2012; Page 1025-1033.   Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2012-5-8-20


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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