ABSTRACT:
Ondansetron HCl melt in mouth tablets were prepared with an intention for quick disintegration of tablet with minimum quantity of water. Reduced quantity of water also has an advantage in antiemetic action. This dosage form was formulated to achieve quick onset of action and maximize oral bioavailability. The purpose of the present research work was to compare the efficiency of different superdisintegrants on the mouth dissolving property of Ondansetron HCl tablets. Melt in mouth tablets of Ondansetron HCl were prepared using croscarmellose sodium, sodium carboxy methyl cellulose, alginic acid, crospovidone and sodium starch glycollate as superdisintegrants by direct compression technique. Prepared tablets were evaluated for weight variation, hardness, friability, content uniformity, wetting time, in vitro dispersion time and dissolution studies. In vitro dispersion time for all the prepared formulations was found to be in following order : In vitro dispersion was found to be rapid in F5 formulation. Sodium starch glycollate (SSG) showed faster dispersion of tablets among all other superdisintegrants.