ABSTRACT:
It is today's need to understand the nanotechnology of manufacturing the ancient conventional drugs which advantages will certainly be more fruitful when reevaluate the standardization of manufacturing process of conventional medicine. As conventional medicine is having a potential risk of interactions between micronutrients affecting absorption and bioavailability. The antimicrobial action of Teminalia chebula especially on gastrointestinal tract is considered in supplementation of soothing to mucosal lining. Haritaki (Terminalia chebula), a common herbaceous plant is extensively used in preparation of many Ayurvedic medicines. Haritaki is used as a purgative, for flatulence, indigestion, gastroenteritis and Vata Dosha. Ellagic acid present in T. chebula has a potent inhibitory action on microorganisms like C. perfringens and E. coli. It is commonly advocated for increasing the gastrointestinal motility thus relieving the symptoms of gastroparesis for better bioavailability and fast absorption of the micronutrient. Fruits contain the chemical substances chebulinic acid, gallic acid and tannic acid. The presence of anthraquinone and sennoside are responsible for the purgative action. Studies have also shown the additional antibacterial activity of T. chebula on Helicobacter pylori. Reports have shown the extract of T. chebula to be effective against a broad spectrum of pathogens comprising of both gram positive as well as gram negative microorganisms. Ethanedoic acid was identified by spectroscopic analysis to be the biologically active compound present in the fruit of T. chebula responsible for the antimicrobial activity especially on gastrointinal mucosa as in broader way microbial biocompatibility to include all of the mechanical, physiological, immunological, cytological, and biochemical responses of the human body. chebula.