ABSTRACT:
Colonic drug delivery is getting importance not only for the treatment of local diseases related to colon but also for the delivery of proteins and therapeutic peptides. Targeting of drug to the colon is widely used for the treatment of colonic diseases like Crohn’s disease, Inflammatory Bowel disease, Cancer, Rheumatoid arthritis, Amoebiasis etc. For this the drug must prevents from degradation or absorption in the hostile condition of stomach. Usual methods for delivering the drug to the last part of Gastro Intestinal Tract that are pH-dependent systems, time-dependent systems, and microbial triggered systems. The Newer technologies namely pressure controlled colonic delivery capsules, CODESTM, and the osmotic controlled drug delivery which are having in vivo site specificity, and feasibility of manufacturing process. This review emphasizes detail information about the primary and novel approaches of the colon targeted drug delivery.