ABSTRACT:
Nephrotoxicity is a poisonous effect of some substances both chemical and medication on kidneys. It is the ninth leading cause of death in United States. Dementia is the loss of memory and cognitive improvement. It is estimated that nearly 13-16 million people will suffer from dementia by 2050. The nature provides a new opportunity to regain all the losses caused by medication or by ageing. Cognitive impairment and chronic kidney disease are becoming increasingly prevalent in the aging US population. A number of herbs traditionally employed in various disease conditions have yielded positive responses. Kidney and brain are the vital organs of the body. Moderate renal impairment, reflected by a higher Serum Creatinine, is associated with an excess risk of incident dementia among individuals in good excellent health. Various herbal drugs such as curcumin, asthwagandha and garlic etc. have been evaluated in both nephrotoxicity and dementia. Various studies revealed that kidney disease exacerbate various cognitive impairments, so the drugs which are beneficial in the kidney disorder can treat various kinds of neuronal disorders. Oxidative stress and inflammation act as the key mediators in kidney and brain disorders, so the drugs with antioxidant potential can be used as a potent target. In this review we will summarize the role of herbs in nephrotoxicity and dementia connecting the link between kidney and brain