ABSTRACT:
These techniques were aimed to develop sustain release formulation of Diclofenac Niosomes in order to provide better therapeutic effect. Diclofenac Niosomes was prepared by different techniques. These are : Ether injection method (F1), Ethanol injection method (F2), Sonication method (F3), Thin film hydration (F4) and Reverse phase evaporation technique (F5) using 1:1:1 ratio of drug, cholesterol and surfactant (Tween 80). The formulations were optimized from the above methods with respect to vesicle shape, particle size, entrapment efficiency, drug content, compatibility studies and in-vitro drug release. The in-vitro release of the drug was consistent. The time course of drugs and their effects in the body are assessed through pharmacokinetics which was provided by mathematical basis. The data collected from the release were incorporated into release kinetic analyses which are Higuchi equation, Korsmeyer-Peppas equations and Hixson-Crowell model along with zero order kinetics and first-order kinetics. The best fit with higher correlation (R2 > 0.98) was found with the Korsmeyer-Peppas equation with the R2 value of 0.993The well spherical shaped Niosomes were obtained in all the methods. FT-IR Spectra shows the drug and excipients were compatible. The in-vitro release studies indicate that all the formulations exhibits retarded release for 24hrs.