ABSTRACT:
Lung cancer is the second most common cancer in India and the most common cause of cancer related deaths. Smoking is one of the most important cause but other factors such as contact with asbestos, radon gas or a lot of air pollution also contribute. Cancer specific drug targeting has been a very actively investigated area for over last two decades. Various approaches have involved in the use of drug delivery systems for localize delivery of anticancer agent at the cancerous site without damaging the normal cells. New approaches to chemotherapy have been shown to improve survival and well being of patients with disease. Chemotherapeutic agents are now being used in conjunction with surgery to reduce the risk of tumor spread. With increasing translational research and a better understanding of the molecular basis of cancer, a number of molecular targets have been identified in various preclinical studies. In this review lung cancer, type, strategies with special emphasis on advancement in treatment of lung cancer by targeted therapies has been discussed in detail.