ABSTRACT:
In the present study, the effect of ethanolic extract of fruit berries of Embelia ribes brum (ER) on milk induced leukocytosis and eosinophilia in mice, compound 48/80 induced mast cell degranulation in rats and egg albumin induced passive paw anaphylaxis in rats was done and in the animal model of milk induced leukocytosis and eosinophilia, ER showed significant decrease in difference in no. of leucocytes and eosinophils count. In the compound 48/80 induced mast cell degranulation in rats, ER showed significant decrease in no. of degranulated mast cells count and significant increase in no. of intact mast cells count. In egg albumin induced passive paw anaphylaxis in rats, ER showed significant reduction in the paw edema volume. Thus these results suggest us that ER may prove to be a potential therapeutic drug for treating allergic diseases such as allergic asthma and the result obtained in this study may be due to its adaptogenic, antistress, mast cell stabilizing, inhibition of AG: AB reaction and anti-inflammatory activities.