ABSTRACT:
With the purpose of development of the rational composition and technology the ointment it was necessary to choose the base. Bases of medicines for local treatment of wounds have an important role in providing their medicinal action. The action of the ointment base determines the use of a medicine according to the phase of the wound process. The frequency of applications required, pharmacokinetic parameters, therapeutically action and the absence or presence of side effects depend on the ointment base. Ointment bases in modern medicines for local treatment of wounds have lost their traditional indication of a passive filler as they become the active components in providing the therapeutic action of the combined medicinal form. These problems were solved on the basis of the experimental research given in this article. The rheological properties of the ointment models bases have been studied. On the basis of the rheological developed optimum composition of ointment’s basis has been choose. The character of influence of active substances by the rheological properties of ointment has been determined. The dependence of a ointment’s rheological properties on a temperature has been studied. The determined that dosage of ointment in tubas it is necessary to make from 25 to 30 °C.