ABSTRACT:
Hydrophilic matrices are an interesting option when developing an oral controlled release formulation. They can be used for controlled release of both water soluble and water insoluble drugs. The aim of this study is to develop stomach specific delivery system of Lamivudine using hydrogel as carrier. Lamivudine hydrogel was developed to prolong gastric residence time and increase its bioavailability. The hydrogels were synthesized using chitosan, Polyvinylpyrrolidone and gelatin. Glutaraldehyde was used as a cross linking agent. The concentration of chitosan was varied and polyvinylpyrrolidone , gelatin were kept constant in all formulations. The prepared hydrogels were characterized by FTIR analysis, scanning electron microscopy and evaluated for drug content, swelling studies, mucoadhesive studies and in vitro drug release. The results showed that the hydrogels were greater in swelling, more mucoadhesive and released drug in a controlled manner upto 12 hrs . F6 was concluded as optimized formulation and subjected for stability testing . The drug release follows zero order kinetics.