ABSTRACT:
Solid lipid nanoparticles (SLN) are the rapidly developing field of nanotechnology with many potential applications in drug delivery and research. Lipid nanoparticles offer possibility to develop new therapeutics, Due to their unique size dependent properties. The ability to incorporate drugs into nanocarriers offers a new method in drug delivery which is used in drug targeting. Hence solid lipid nanoparticles hold great importance in control and site specific drug delivery and hence attracted wide attention of researchers. This review includes a broad treatment of solid lipid nanoparticles discussing their aims, production procedures, advantages, limitations, sterilization and their possible remedies. Appropriate analytical techniques for the characterization of Solid lipid nanoparticles like scanning electron microscopy, photon correlation spectroscopy, and differential scanning calorimetry are highlighted. Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, clinical medicine, cosmetics, research, and other allied sciences. Solid lipid nanoparticles are colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. Proteins and antigens may be incorporated or adsorbed onto Solid lipid nanoparticles which are intended for therapeutic purposes, and they can be administered by parenteral routes or by alternative routes such as nasal, oral, and pulmonary. The obstacles associated with conventional chemotherapy may be partially overcome by encapsulating them as SLN. The present review focuses on the utility of Solid lipid nanoparticles in terms of their advantages, production methodology, characterization and applications. If they are properly investigated, SLNs may open new vistas in therapy of complex diseases.