ABSTRACT:
Gingivitis and periodontitis are chronic inflammatory conditions which are the most prevalent disease in humankind. A clinical periodontal practice where saliva is served as an important and convenient vehicle to evaluate factors that could predict the burst activity known to occur in the progression of periodontitis. Saliva as a mirror of oral and systemic health, is a valuable source as it contains biomarkers specific for unique physiologic aspects of periodontal diseases. T he salivary biomakers are specific for three aspects of periodontitis-inflammation, collagen degradation and bone turn over.Saliva is attractive for diagnostic purposes greatly due to its highly enriched content of disease biomarkers that can be analyzed. These properties of saliva open doors to a perfect method of exploring health and disease surveillance in clinical settings with just a minute amount of oral fluid. In oral diagnostics, it has been a great challenge to determine biomarkers for screening, prognosis and evaluating the disease activity and the efficacy of the therapy.