ABSTRACT:
The objective of this study was to develop the Losartan potassium sustained release tablets. This can be achieved by formulating tablets by direct compression method, by employing semi-synthetic and natural polymers like HPMCK100M, Carbopol 934 and Xanthan gum in various concentrations. The powdered blend evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The results obtained were satisfactory. Compressed formulations were further evaluated for thickness, friability, and hardness, swelling index and in-vitro dissolution studies. All the formulations showed good results, which were in compliance with Pharmacopoeia standards. A response surface methodology was used to select the optimized formulation wherein types of polymer and concentration of polymer were taken as independent variables and amount of drug release was taken as dependent variables. Optimization studies were carried out by using the Design Expert software version 8.0.1. The in vitro drug release followed Zero Order model and the drug release mechanism was found to be Non-Fickian type.