Author(s): D. Benito Johnson, Faisal Mohammad Ali Abdalla, Abdulaziz


DOI: Not Available

Address: D. Benito Johnson*, Faisal Mohammad Ali Abdalla, Abdulaziz
Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamil Nadu.
*Corresponding Author

Published In:   Volume - 7,      Issue - 12,     Year - 2014

Cancer results from a series of molecular events that fundamentally alter the normal properties of cells in our body. The normal control systems in cancer cells that prevent cell overgrowth and the invasion of other tissues are disabled. Treatment for cancer should not begin until the presence of cancer is confirmed by a tissue (i.e., histologic) diagnosis. Chemoprotective agents are the drugs that are used with certain types of chemotherapy to protect the body from or minimize the side effects of the chemotherapy. Chemoprotective agents include amifostine, mesna and dexrazoxane. The present study is done to evaluate the chemoprotective efficacy of the Plant Gmelina arborea against cyclophosphamide induced toxicity, as the well known cancer treating drug has number of side effects especially toxicity towards hematopoetic system.

Cite this article:
D. Benito Johnson, Faisal Mohammad Ali Abdalla, Abdulaziz. Evaluation of the Chemoprotective Activity of 70% Methanolic Extract of Gmelina arborea Stem Bark against Cyclophosphamide Induced Toxicity. Research J. Pharm. and Tech. 7(12): Dec. 2014; Page 1420-1428.

D. Benito Johnson, Faisal Mohammad Ali Abdalla, Abdulaziz. Evaluation of the Chemoprotective Activity of 70% Methanolic Extract of Gmelina arborea Stem Bark against Cyclophosphamide Induced Toxicity. Research J. Pharm. and Tech. 7(12): Dec. 2014; Page 1420-1428.   Available on:

1.    Adel RA Abd-Allah, Ali M Gado, Abdulhakeem A Al-Majed, Abdulaziz A Al-Yahya and Othman A Al-Shabanah (2004). Protective effect of taurine against cyclophosphamide-induced urinary bladder toxicity in rats. Clinical and Experimental Pharmacology and Physiology 31: 167–172.
2.    Ahmad S, Mika D and Guruvayoorappan C (2012). Chemoprotective and Immunomodulatory effect of Acacia nilotica during cyclophosphamide induced toxicity. Journal of Experimental Therapeutics and Oncology 10(2): 83-90.
3.    Ali Shalizar Jalali, Shapour Hassanzadeh and Hassan Malekinejad (2011). Chemoprotective effect of Crataegus monogyna aqueous extract against cyclophosphamide-induced reproductive toxicity. Veterinary Research Forum 2 (4): 266 – 273.
4.    Ambujakshi H R, Thakar H and Shyamnanda (2009). Anthelmentic activity of Gmelina arborea Roxb Leaves extract. Indian Journal of Pharmaceutical Research and Development 1(9):1-5.
5.    Anamika Gupta, Manish K Gautam, Rahul K Singh, M Vijay Kumar, Ch V Rao, R K Goel and Shamba Anupurba (2010). Immunomodulatory effect of Moringa oleifera Lam. extract on cyclophosphamide induced toxicity in mice. Indian Journal of Experimental Biology 48 (11): 1157-1160.
6.    Anjaneyulu A S R, Jaganmohan Rao K, Kameswara Rao V, Ramachandra Row L, Subrahmanyam C, Pelter A and Ward R S (1975). The structures of lignans from Gmelina arborea Linn. Tetrahedron 31(10): 1277–1285.
7.    Anjaneyulu A S R, Madhusudhana rao A, Kameswara Rao V and Ramachandra Row L (1977). Novel hydroxy lignans from the heartwood of Gmelina arborea. Tetrahedron 33 (1): 133–143.
8.    Anuj M Pandey and Yogesh Kulkarni (2010). Evaluation of antioxidant activity of Gmelina arborea extracts by invitro techniques. Pharmacologyonline 2: 805-811.

9.    Arvigo R and Balick M (1993). Rainforest Remedies, Lotus Press, Twin Lakes.
10.    Balandrin N F, Kinghorn A D and Farnsworth N R (1993). Human medicinal agents from plants. ACS Symposium Series 534: 2-12.
11.    Balu N, Gamcsik M P, Colvin M E, Colvin O M, Dolan M E, Ludeman S M(2002). Modified guanines representing O6-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: synthesis, stability and ab initio studies. Chemical Research in Toxicology 15: 380–387.
12.    Brock N and Hohorst H J (1967). Metabolism of cyclophosphamide. Cancer 20: 900-04.
13.    Carol McManus Balmer, Amy Wells Valley and Andrea Iannucci (2005). Cancer treatment and chemotherapy. Pharmacotherapy: A Pathophysiologic Approach, Sixth Edition, McGRAW-HILL publications, USA: 2279-2281
14.    Chabner B A, and Roberts T G(2005). Timeline: Chemotherapy and the war on cancer. Nature Reviews Cancer 5: 65-72.
15.    Chabner B A and Longo D L (1996). Clinical strategies for cancer treatment: The role of drugs. Cancer Chemotherapy and Biotherapy: Principles and Practice. Philadelphia, Lippincott-Raven:1–16.
16.    Chahoud I, Ligensa A, Dietzel L and Faqui A S (1999). Correlation between maternal toxicity and embryo/fetal effects. Reproductive Toxicology 13: 375-381.
17.    Charles R Craig and Robert E Stitzel (2004). Modern pharmacology with clinical applications. Sixth edition, Lippincott Williams and Wilkins Publishers, USA: 639-640.
18.    Charles R. Craig and Robert E (2004). Modern pharmacology with clinical applications. Lippincott Williams and Wilkins Publishers, USA: 508-509.
19.    Chelikani P, Fita I and Loewen P C (2004). Diversity of structures and properties among catalases. Cellular and Molecular Life Sciences 61 (2): 192–208.
20.    Clemons M and Goss P (2001). Estrogen and the risk of breast cancer. The New England Journal of Medicine 344: 276–285.
21.    Colleoni M, Rocca A, Sandri M T, Zorzino L, Masci G, Nole F, Peruzzotti G, Robertson C, Orlando L, Cinieri S, de Braud F, Viale G and Goldhirsch A (2001). Low dose oral methotrexate and cycophosphamide in metastatic breast cancer: antitumour activity and correlation with vascular endothelial growth factor levels. Annals of Oncology 13: 73-80.
22.    Cragg G M, Newman D J and Weiss R B (1997). Coral reefs, forests, and thermal vents: the worldwide exploration of nature for novel antitumor agents. Seminars in Oncology 24: 156–163.
23.    Dupont W D and Page D L (1991). Menopausal estrogen replacement therapy and breast cancer. Archives of Internal Medicine 151: 67–72.
24.    Duthie G G and Brown K M (1994). Reducing the risk of cardiovascular disease. Functional Foods, Aspen publication: New York: 19-38.
25.    El-Mahmood A M, Doughari J H and Kiman H S (2010).  In vitro antimicrobial activity of crude leaf and stem bark extracts of Gmelina arborea (Roxb) against some pathogenic species of Enterobacteriaceae. African Journal of Pharmacy and Pharmacology 4(6): 355-361.

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