Author(s): Ghule Arpan R.1*, Shinkar Dattatraya M.1, Saudagar Ravindra B.2

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Address: 1Department of Pharmaceutics, KCT’S RGS College of Pharmacy, Anjaneri, Nashik.422213.Maharashtra, India. 2Department of Pharmaceutical CHEMISTRY, KCT’S RGS College of Pharmacy, Anjaneri, Nashik.422213.Maharashtra, India.

Published In:   Volume - 8,      Issue - 1,     Year - 2015


ABSTRACT:
Oral Strip Technology (OST) is gaining much attention. The advantages of OST are the administration to pediatric and geriatric patient population where the difficulty of swallowing larger oral dosage forms is eliminated. This technology has been used for local action, rapid release products and for mucoadhesive systems that are retained for longer period in the oral cavity to release drug in controlled fashion. OST offers an alternate platform for molecules that undergo first pass metabolism and for delivery of peptides. An ideal OST should have the following properties: high stability, transportability, ease of handling and administration, no special packaging material and/or processing requirements, no water necessary for application and a pleasant taste. These entire requirements are fulfilled by the oral films. The OST is a good tool for product life cycle management for increasing the patent life of existing molecules or products. Compared to some of the complicated and expensive process (like lyophilization) used to manufacture ODTs (Orally Disintegrating Tablets), the OST is relatively easy to fabricate, thus reducing the overall cost of the therapy. One of the reasons is that the buccal mucosa is less permeable and is thus not able to elicit a rapid onset of absorption and hence better suited for formulations that are intended for sustained release action. Further, the buccal mucosa being relatively immobile mucosa and readily accessible, it makes it more advantageous for retentive systems used for oral Tran’s mucosal drug delivery. The primary disadvantage associated with buccal delivery route is the low flux that in turn results in low drug bioavailability. To overcome this hurdle, various buccal penetration enhancers have been studied which improve the absorption pattern of the molecules. The article shows OST encompassing materials used in OST, method of Preparation, Evaluation, Applications, Commercial technologies and future Business prospects of this technology. The oral film is manufacture using solvent casting method, rolling method, extrusion method and solid dispersion method.


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