ABSTRACT:
The present study was to investigate the in vitro antipsoriatic activity of the successive solvent extracts of Barleria gibsoni Dalz. leaves against HaCa T keratinocyte cells. Asiaticoside was given as reference drug. The plant material was dried under shade, powdered and extracted with different solvent extract like Petroleum ether, chloroform, ethyl acetate and ethanol. Preliminary phytochemical screening was done. 50% cell growth inhibition (IC50) of successive solvent extract of Barleria gibsoni and Asiaticoside was 576.82 µg/ml and 460.13µg/ml against the HaCa T keratinocyte cells. Petroleum ether and ethanol extract of Barleria gibsoni and Asiaticoside was effective cytotoxic drugs against HaCa T keratinocyte cells. It is due to the extraction of active compounds in the Petroleum ether and ethanolic extract. Therefore, it is suggested that evaluation of active constituents and clinical evaluation of petroleum ether extract of Barleria gibsoni would give a encouraging lead in the successful management of psoriasis.