ABSTRACT:
A growing threat of resistance to antibiotics by various microorganisms, an attempt has been made to identify the potent Aryl imidazole derivatives for its antimicrobial activities. A series of Aryl imidazole derivatives were synthesized by the condensation of various primary aromatic amines with aromatic aldehyde to form respective schiff’s base which on further undergone reaction with ammonium acetate and Isatin in presence of glacial acetic acid to form the title compounds. The structures of the synthesized compounds were characterized by FT-IR, 1H-NMR and 13C-NMR spectral studies. Based on AutoDock score, the potent aryl imidazole derivatives were selected for their Antimicrobial study. The screened compounds showed moderate to good antibacterial activity against Staphylococcus aureus, Bacillus cereus, E.coli, Salmonella typhi when compared to standard (Ciprofloxacin-30mcg/disc). In the antifungal study among the screened compounds, JG3 only showed moderate antifungal activity against Candida albicans when compared to standard (Clotrimazole-30mcg).