ABSTRACT:
The present investigation is an attempt to study the formulation and evaluation of matrix tablet of Metformin HCl using natural mucilage of Cassia tora as a release retardant. The matrix tablet was formulated using different drug polymer ratio. The result of the pre-compression parameter like bulk density, tapped density, carr’s index and hausner ratio were found to be with the limits indicating good flow properties of the granules. Swelling index was found proportional to the concentration of mucilage. Formulation F-2 and F-3 showed 61% and 89.9 % respectively of swelling at the end of 5 h. In-vitro drug release for F3 formulation was found to be 75% at the end of 10 h. Drug release study has been suggested that release of drug from the matrix tablet get retarded with increasing mucilage concentration. Drug release profile of all formulations was plotted with different kinetics models. The regression coefficients showed best fit with higuchi model (r2= 0.958).