ABSTRACT:
Aim: To make a review on Antioxidant level in oral malignant condition. Background: Cancer is the leading cause of death worldwide. Tobacco is the major cause of oral cancer. In many studies shows, reactive oxygen species (ROS) like super oxide radicals, hydroxyl radicals and hydrogen peroxide play a key role in human cancer development. As a consequence of normal metabolic process ROS recontinuously produced in the human body. Normally our body has several defence system to scavenge the ROS and protect our body from damage. The defence system contain Antioxidants, which is defined as any substance that when present in low concentration compared to that of an oxidizible substrate, significantly delays or inhibits the oxidation of that substrate. In normal cells there is an appropriate prooxidant:oxidant balance. When ROS level is increased, pro-oxidant level will increased and antioxidant level will decreased. This state is called oxidative stress which causes severe cell damage. Oxidative stress is the major cause of progression of many chronic Inflammatory diseases like atherosclerosis, Neuro degenerative diseases and carcinogenesis. Reason: So oxidants and Antioxidants play an importance role in the development and progression of cancer. So in this study, I will review the level of antioxidants in oral cancer.