Author(s):
S. Bose, H. Shinde, K. Karikalan, P. Lalitha, A. K. A. Mandal
Email(s):
akamandal@rediffmail.com
DOI:
10.5958/0974-360X.2016.00483.2 
Address:
S. Bose1, H. Shinde1, K. Karikalan1, P. Lalitha2, A. K. A. Mandal1*
1School of Bio Sciences and Technology, VIT University, Vellore - 632014, Tamil Nadu, India.
2Biotechnology Laboratory, Podicherry University, Pondicherry – 605014, India.
*Corresponding Author
Published In:
Volume - 9,
Issue - 12,
Year - 2016
ABSTRACT:
Aqueous extract from Azadirachta indica leaves was used for green synthesis of silver nanoparticles (NPs). UV-visible spectrometry, and particle size analysis confirmed formation of silver NPs of 10-100 nm in size. Transmission electron microscopic observation and X-ray diffraction data showed that spherical particles were crystalline in nature with an average crystallite size of 24 nm. Fourier transform infrared spectroscopic analysis showed efficient capping of the NPs by the phytochemicals present in the leaf extract. NPs showed good antibacterial activity against Escherichia coli and Pseudomonas aeruginosa and potent anti-inflammatory activity at very low concentration, for PBMC and RAW264.7 cells as well as anti-proliferative activity against HT29 cell line.
Cite this article:
S. Bose, H. Shinde, K. Karikalan, P. Lalitha, A. K. A. Mandal. Antibacterial, Antiinflamatory, and Antiproliferative Activity of Silver Nanoparticles Synthesized from Leaf Extract of Azadirachta indica A. Juss. Research J. Pharm. and Tech 2016; 9(12):2422-2426. doi: 10.5958/0974-360X.2016.00483.2
Cite(Electronic):
S. Bose, H. Shinde, K. Karikalan, P. Lalitha, A. K. A. Mandal. Antibacterial, Antiinflamatory, and Antiproliferative Activity of Silver Nanoparticles Synthesized from Leaf Extract of Azadirachta indica A. Juss. Research J. Pharm. and Tech 2016; 9(12):2422-2426. doi: 10.5958/0974-360X.2016.00483.2 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2016-9-12-60