ABSTRACT:
Purpose: To develop and evaluate a model lozenge from Moringa oleifera leaf extract. Methods: Lozenge from M. oleifera leaf extract was developed and formulated using wet granulation technique. Lozenges were evaluated for physicochemical properties such as thickness, hardness, friability and weight variation. Assay of quercetin content was also determined by HPLC for the preliminary stability testing and drug released study. Results: The appropriate lozenge formulation containing M. oleifera leaf extract powder, polyvinylpyrrolidone, magnesium stearate, menthol and vanillin showed a good physicochemical properties which all the criteria value were in the acceptable range. Moreover, the microbial testing showed no contamination of any microorganisms in proper formulations. Conclusion: The results indicated the development of a suitable lozenge formulation from M. oleifera leave extract which should be further study and apply to the other herbal formulations in the future.