ABSTRACT:
In the present paper, a series of substituted 1,3,4-oxadiazoles have been synthesized by three different methods i.e. conventional heating, microwave irradiation method 1 and microwave irradiation method 2. Conventional heating, microwave irradiation method 1 and microwave irradiation method 2 were compared in terms percent yield, reaction time, percent atom economy and environment quotient (eco-friendly). The results showed that microwave irradiation method 2 was remarkably greener and ecofriendly than microwave irradiation method 1 and conventional heating. Derivatives of 1,3,4-oxadiazoles were characterized on the basis of IR, 1H NMR and Mass spectral data and the structures of the synthesized compounds were confirmed. All compounds were screened for their in vitro antibacterial, antitubercular and antifungal activity. However the results indicated that the synthesized compounds have less activity with reference to their respective standards.