ABSTRACT:
Metoprolol succinate is a selective beta receptor blocker having poor physico-chemical and micromeritic properties. Therefore the co-crystals of metoprolol have been attempted to improve its physic-chemical and micromeritic characteristics. The effect of different co-formers such as benzoic acid and salicylic acid on flow ability of metoprolol by co-crystal technique. The co-crystals were characterized by Infra-red spectroscopy(I.R).It was found that micromeritic properties such as angle of repose, and physicochemical properties such as melting point. of co-crystals were significantly improved than that of pure metoprolol succinate. Hence it could be concluded that co-crystals could be one of the effective approaches for improved performance of metoprolol succinate.
Cite this article:
Sachin S. Mali, Suresh G. Killedar. To Enhance the Physicochemical Properties of Metoprolol Succinate By Co-Crystal Technique. Research J. Pharm. and Tech 2017; 10(11): 3761-3767. doi: 10.5958/0974-360X.2017.00683.7
Cite(Electronic):
Sachin S. Mali, Suresh G. Killedar. To Enhance the Physicochemical Properties of Metoprolol Succinate By Co-Crystal Technique. Research J. Pharm. and Tech 2017; 10(11): 3761-3767. doi: 10.5958/0974-360X.2017.00683.7 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2017-10-11-21