Author(s):
Pankaj Kumar, Abhishek Kumar, Deeksha S, Nireeksha G, Shalet D’Souza
Email(s):
abhi12bunty@gmail.com
DOI:
10.5958/0974-360X.2017.00252.9 
Address:
Pankaj Kumar, Abhishek Kumar*, Deeksha S, Nireeksha G, Shalet D’Souza
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka.
*Corresponding Author
Published In:
Volume - 10,
Issue - 5,
Year - 2017
ABSTRACT:
The appearance to antimicrobial resistance to the antimicrobial agent has become a matter of high concern for health care professionals since last ten years. It will an effort to establish new phenylpropenone pyrrolyl; chalcones as improved antimicrobial agent. In this particular series of novel substituted phenylpropenone pyrrol (AP1-AP5) were synthesized by simple condensation reaction between different substituted aldehydes and 3 acetyl -2,4-dimethyl pyrrole in presence of a strong ethanolic base to yield the chalcones. The structures of the final synthesized compounds were characterized by IR, mass and 1H NMR spectra. The synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosaby cup plate method. Most of the compounds exhibited promising antibacterial activity
Cite this article:
Pankaj Kumar, Abhishek Kumar, Deeksha S, Nireeksha G, Shalet D’Souza. Synthesis and Antimicrobial Evaluation of Different Substituted Phenylpropenone Pyrrolyl Chalcones. Research J. Pharm. and Tech. 2017; 10(5): 1426-1428. doi: 10.5958/0974-360X.2017.00252.9
Cite(Electronic):
Pankaj Kumar, Abhishek Kumar, Deeksha S, Nireeksha G, Shalet D’Souza. Synthesis and Antimicrobial Evaluation of Different Substituted Phenylpropenone Pyrrolyl Chalcones. Research J. Pharm. and Tech. 2017; 10(5): 1426-1428. doi: 10.5958/0974-360X.2017.00252.9 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2017-10-5-27