ABSTRACT:
Transethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and the systemic circulation. Although transethosome systems are conceptually sophisticated, they are simple in their preparation, safe for use a combination that can highly expand their application. Transethosome are gaining popularity in designing drug delivery systems for topical and transdermal use for their capability to reach deep skin layers and systemic circulation. The dermal route has been recognized as one of the highly potential routes of systemic drug delivery and provide the advantage of avoidance of the first pass effect, ease of use and withdrawal (in case of side effects) and better patient compliance. Transethosome have both ethanol and penetration enhancer due to which drug penetrates through stratum corneum by increase fluidity of cell membrane lipids. The present review includesthe composition, mechanism of penetration, advantage, method of preparation and characterization of transethosome.