ABSTRACT:
Biotransformation of chiral intermediates using micro-organism has widely used in many industries due to green technology and cost effectiveness. Moreover, Enzymes are highly ‘Chemo-, regio-, and enantio-selective’ in nature. From decades, bio-reduction performed using whole cells and free enzymes for the production of chiral alcohols. Some recent developments in the area of fermentative biotransformation processes for the reduction of Keto- sulfone to hydroxy sulfone and Lipitor intermediate are reviewed and importance of microbial mediated asymmetric synthesis of chiral alcohols are highlighted for the future perspective.
Cite this article:
Saravanan J, Suneetha V. Asymmetric Synthesis of Chiral Alcohols for API Production using Microorganisms - A Mini Review. Research J. Pharm. and Tech. 2017; 10(6): 1881-1885. doi: 10.5958/0974-360X.2017.00330.4
Cite(Electronic):
Saravanan J, Suneetha V. Asymmetric Synthesis of Chiral Alcohols for API Production using Microorganisms - A Mini Review. Research J. Pharm. and Tech. 2017; 10(6): 1881-1885. doi: 10.5958/0974-360X.2017.00330.4 Available on: https://www.rjptonline.org/AbstractView.aspx?PID=2017-10-6-54